Research Outputs | Dr Julien V Brugniaux

1. Cochand, N.J., Wild, M., Brugniaux, J.V., Davies, P.J., Evans, K.A., Wise, R.G. and Bailey, DM. (2011). Sea-level assessment of cerebral autoregulation predicts susceptibility to acute mountain sickness. Stroke 42: 3628-3630.

Study funded by the British Mt. Everest Foundation (c/o Bailey). First ever human study to demonstrate that the subtle imperfections in dynamic cerebral autoregulation at sea-level can successfully predict the severity of acute mountain sickness (AMS) following ascent to high-altitude. These haemodynamic biomarkers are currently being considered to predict AMS susceptibility during (rapid ascent) commercial expeditions to high-altitude given the financial implications associated with insurance and indemnity – eg. the high-profile Kili-Captains Rugby Expedition

2. Brugniaux, J.V., Pialoux, V., Foster, G.E., Duggan, C.T., Eliasziw, M., Hanly, P.J. and Poulin, M.J. (2011). Effects of intermittent hypoxia on erythropoietin, soluble erythropoietin receptor and ventilatory patterns in healthy humans. European Respiratory Journal 37:880-7

First ever human study to demonstrate that ventilatory acclimatisation to hypoxia is mediated in part by changes in the blood-borne concentration of erythropoietin (EPO) and soluble EPO receptors. Brugniaux received two research grants (Postdoctoral fellowships from the Hotchkiss Brain Institute and the Heart & Stroke Foundation of Canada) for this project (CAD$166,000, £100,000 equivalent).

3. Beaudin, A.E., Brugniaux, J.V., Vohringer, M., Flewitt, J., Green, J.D., Friedrich, M.G. and Poulin, M.J. (2011). Cerebral and myocardial blood flow responses to hypercapnia and hypoxia in humans. American Journal of Physiology (Heart and Circulatory Physiology) 301:H1678-H1686.

Human study that investigated the extent to which the cerebral and coronary vasculatures differ in their responses to euoxic hypercapnia and isocapnic hypoxia in healthy volunteers. The findings demonstrate that compared to the coronary circulation, the cerebral circulation is more sensitive to hypercapnia but equally sensitive to hypoxia.

4. Foster, G.E., Brugniaux, J.V., Pialoux, V., Duggan, C.T., Hanly, P.J., Ahmed, S.B. and Poulin, M.J. (2009). Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans. Journal of Physiology 587: 3287-3299.

Study determined effects of intermittent hypoxia (IH) on the cardiovascular and cerebrovascular response to acute hypoxia and hypercapnia in an experimental human model that simulates the hypoxaemia experienced by obstructive sleep apnoea (OSA) patients. Findings demonstrate that IH alters blood pressure and cerebrovascular regulation, which is likely to contribute to the pathogenesis of cardiovascular and cerebrovascular disease in patients with OSA. This study has been funded in part by the Hotchkiss Brain Institute and the Heart & Stroke Foundation of Canada (c/o Brugniaux).