1. Murrell, C.J., Cotter, J.D., Thomas, K.N., Lucas, S.J., Williams, M.J. and Ainslie, P.N. (2013). Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training.
Age 35: 905-920.
First ever human interventional study demonstrating aerobic exercise training-induced improvements in human cerebral haemodynamic function. This important information provides support for exercise as a prophylactic countermeasure against the neurological diseases associated with human ageing.
2. Marsden, K.R., Haykowsky, M.J., Smirl, J.D., Jones, H., Nelson, M.D., Altamirano-Diaz, L.A., Gelinas, J.C., Tzeng, Y.C., Smith, K.J., Willie, C.K., Bailey, D.M. and Ainslie, P.N. (2012). Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise.
Age 34: 725-735.
Human study that provides mechanistic insight into the control of cerebral blood flow (CBF) during acute exercise in the aged. Compared to young controls, aged participants exhibited a suppressed exercise-induced increase in CBF despite less hypocapnic-induced cerebral vasoconstriction.
3. Geinas, J.C., Marsden, K.R., Tzeng, Y.C., Smirl, J.D., Smith, K.J., Willie, C.K., Lewis, N.C., Binsted, G., Bailey, D.M., Bakker, A., Day, T.A. and Ainslie, P.N. (2012). Influence of posture on the regulation of cerebral perfusion.
Aviation, Space and Environmental Medicine 83: 751-757
Human study demonstrating that CBF is well-maintained during marked changes in perfusion pressure following postural changes. These mechanistic findings have implications for the aged who when syncopal during orthostatic stress are more at risk of falling.
4. Ainslie, P.N., Cotter, J.D., George, K.P., Lucas, S., Murrell, C., Shave, R., Thomas, K.N., Williams, M.J. and Atkinson, G. (2008). Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing.
Journal of Physiology 15: 4005-4010.
Cross-sectional study that provides the first ever human evidence to suggest that regular aerobic-endurance exercise is associated with elevated cerebral perfusion across the human lifespan. This provides complementary mechanistic insight into why increased physical activity is neuroprotective and can prevent stroke and dementia.