Research Outputs | Dr Karl New

1. New, K.J., Reilly, M.E., Templeton, K., Ellis, G., James, P.E., Mceneny, J., Penney, M., Hooper, J., Hullin, D., Davies, B. and Bailey DM. (2013)
Free radical-mediated lipid peroxidation and systemic nitric oxide bioavailability: implications for postexercise hemodynamics American Journal of Hypertension 26: 126-134.

First ever human study to evaluate the impact of exercise-induced nitric oxide (NO) bioavailability on systemic blood pressure in hypertensive individuals. The findings demonstrate that moderate aerobic exercise lowers immediate post-exercise blood pressure without increasing circulating NO but with increased oxidative stress. This highlights the potential beneficial role that free-radicals may play in vascular function in this population. Work recognised with the Pollock Award by the American College of Sports Medicine.

2. Bailey, D.M., Jones, D.W., Sinnott, A., Brugniaux, J.V., New, K.J., Hodson, D., Marley, C.J., Smirl, J.D. and Ainslie, P.N (2013).
Impaired cerebral hemodynamic function in professional boxers. Clinical Science 124: 177-189.

First ever human study to demonstrate that dynamic cerebral autoregulation, carbon dioxide vasoreactivity and cortical oxygenation are selectively impaired in professional boxers. Findings provide the first mechanistic basis why chronic traumatic brain injury is a progressive disease that manifests beyond the active boxing career. Paper presented by Bailey as an International Keynote at Irish Institute of Clinical Neuroscience (Boxing and the Brain), Dublin November 23rd, 2012 and generated considerable media interest including commentaries on the Fight Medicine webpage.

Also stimulated strategic collaboration with Prof Ann McKee (Boston University School of Medicine, USA), the world’s foremost authority on traumatic encephalopathy.

3. Bailey, D.M., Marley, C.J., Brugniaux, J.V., Hodson, D., New, K.J., Ogoh, S. and Ainslie, P.N. (2013). Elevated aerobic fitness sustained throughout the adult lifespan is associated with improved cerebral hemodynamics. Stroke 44: 3235-3238.

First ever human study to determine the association between aerobic fitness and both cerebral perfusion and cerebrovascular reactivity (to carbon dioxide) across the continuum of healthy human ageing. Collectively, the findings highlight the importance of being physically active and maintaining aerobic fitness throughout the lifespan given clear cerebrovascular benefits and potential to reduce stroke risk and susceptibility to dementia in later-life.