1. Wray, D.W., Nishiyama, S.K., Harris, R.A., Zhao, J., McDaniel, J., Fjeldstad, A.S., Witman, M.A., Ives, S.J., Barrett-O’Keefe, Z. and Richardson, R.S. (2012). Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption.
Hypertension 59: 818-824.
Novel human study showing that oral antioxidant consumption acutely restores “impaired” endothelial function in the aged while disrupting “normal” endothelium-dependent vasodilatation in the young due to changes in free radical metabolism.
2. Bailey, D.M., McEneny, J., Mathieu-Costello, O., Henry, R.R., James, P.E., McCord, J.M., Pietri, S., Young, I.S. and Richardson, R.S. (2010). Sedentary aging increases resting and exercise-induced intramuscular free radical formation
Journal of Applied Physiology 109: 449-456
First ever human study using direct molecular techniques to show that intramuscular free radical formation is elevated in aged compared to young skeletal muscle both at rest and in response to an acute exercise challenge. First human evidence to support the “Free Radical Theory of Ageing” postulated over half a century ago.
3. Donato, A.J., Uberoi, A., Bailey, D.M., Wray, D.W. and Richardson, R.S. (2010). Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.
American Journal of Physiology (Heart and Circulatory Physiology) 298: H671-H678.
4. Wray, D.W., Uberoi, A., Lawrenson, L., Bailey, D.M. and Richardson, R.S. (2009). Oral antioxidants and cardiovascular health in the exercise-trained and untrained elderly: a radically different outcome.
Clinical Science 116: 433-441.
First ever human studies to document the interaction between free radicals and vascular endothelial function in the aged as a function of exercise training status. Contrary to conventional wisdom, antioxidant prophylaxis in the aged “following exercise training” was shown to impair (rather than improve) vascular endothelial function with return to a hypertensive state. Collectively, these paradoxical findings have important clinical implications and suggest a need for caution when combining exercise and acute antioxidant supplementation in the aged.